01 - Heat a large skillet over medium-high heat. Add ground beef and season with salt, pepper, garlic powder, and onion powder. Cook, breaking up the meat with a spatula, until browned and cooked through, approximately 6–8 minutes. Drain excess fat if necessary.
02 - While the beef cooks, combine mayonnaise, ketchup, mustard, white vinegar, pickle relish, and smoked paprika in a small bowl. Whisk until smooth and fully incorporated. Set aside until ready to serve.
03 - Divide chopped lettuce evenly among four serving bowls. Arrange cherry tomatoes, red onion slices, shredded cheddar cheese, and dill pickle slices on top of the lettuce.
04 - Spoon the cooked ground beef over the prepared salad bases, distributing evenly among the four bowls.
05 - Drizzle each bowl generously with the prepared burger sauce. Top with sliced avocado, crumbled bacon, and sesame seeds if desired. Serve immediately while the beef is still warm.